CXCR4 inhibition in tumor microenvironment facilitates anti-PD-1 immunotherapy in sorafenib-treated HCC in mice

Sorafenib—a broad tyrosine kinase inhibitor—is the only approved systemic therapy for advanced hepatocellular carcinoma (HCC), but provides limited survival benefits. Recently, immunotherapy has emerged as a promising treatment strategy, but its role remains unclear in HCCs, which are associated wit...

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Foilsithe in:Hepatology
Main Authors: Chen, Yunching, Ramjiawan, Rakesh R., Reiberger, Thomas, Ng, Mei R., Hato, Tai, Huang, Yuhui, Ochiai, Hiroki, Kitahara, Shuji, Unan, Elizabeth C., Reddy, Tejaswini P., Fan, Christopher, Huang, Peigen, Bardeesy, Nabeel, Zhu, Andrew X., Jain, Rakesh K., Duda, Dan G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406806/
https://ncbi.nlm.nih.gov/pubmed/25529917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27665
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