p38 mitogen-activated protein kinase inhibits tristetraprolin-directed decay of the mRNA of the anti-inflammatory cytokine interleukin-10

p38 mitogen-activated protein kinase (MAPK) stabilises mRNAs of pro-inflammatory mediators by inhibiting AU-rich element-mediated decay. We show that in bone marrow-derived macrophages (BMDM) tumour necrosis factor (TNF) mRNA is stabilised by inactivation of the AU-rich element-binding protein trist...

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Detalhes bibliográficos
Publicado no:FEBS Lett
Main Authors: Tudor, Corina, Hitti, Edward, Rawlinson, Lesley, Blackshear, Perry J., Gaestel, Matthias, Clark, Andrew R., Saklatvala, Jeremy, Dean, Jonathan L.E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798241/
https://ncbi.nlm.nih.gov/pubmed/19416727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2009.04.039
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