Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Regulates Tumor Necrosis Factor mRNA Stability and Translation Mainly by Altering Tristetraprolin Expression, Stability, and Binding to Adenine/Uridine-Rich Element

The mitogen-activated protein kinase (MAPK) p38/MAPK-activated protein kinase 2 (MK2) signaling pathway plays an important role in the posttranscriptional regulation of tumor necrosis factor (TNF), which is dependent on the adenine/uridine-rich element (ARE) in the 3′ untranslated region of TNF mRNA...

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Bibliografiska uppgifter
Huvudupphovsmän: Hitti, Edward, Iakovleva, Tatiana, Brook, Matthew, Deppenmeier, Stefanie, Gruber, Achim D., Radzioch, Danuta, Clark, Andrew R., Blackshear, Perry J., Kotlyarov, Alexey, Gaestel, Matthias
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2006
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1430282/
https://ncbi.nlm.nih.gov/pubmed/16508014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.6.2399-2407.2006
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