MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment

Tristetraprolin (TTP) directs its target AU-rich element (ARE)-containing mRNAs for degradation by promoting removal of the poly(A) tail. The p38 MAPK pathway regulates mRNA stability via the downstream kinase MAPK-activated protein kinase 2 (MAPKAP kinase 2 or MK2), which phosphorylates and prevent...

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Autors principals: Marchese, Francesco P., Aubareda, Anna, Tudor, Corina, Saklatvala, Jeremy, Clark, Andrew R., Dean, Jonathan L. E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934626/
https://ncbi.nlm.nih.gov/pubmed/20595389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.136473
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