KLF4 is essential for induction of cellular identity change and acinar-to-ductal reprograming during early pancreatic carcinogenesis

Understanding the molecular mechanisms of tumor initiation has significant impact on cancer early detection and intervention. To define the role of KLF4 in pancreatic ductal adenocarcinoma initiation, we used molecular biological analyses and mouse models of klf4 gain- and loss-of-function and mutan...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Wei, Daoyan, Wang, Liang, Yan, Yongmin, Jia, Zhiliang, Gagea, Mihai, Li, Zhiwei, Zuo, Xiangsheng, Kong, Xiangyu, Huang, Suyun, Xie, Keping
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794756/
https://ncbi.nlm.nih.gov/pubmed/26977883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.02.005
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