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Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia
Efforts to model pancreatic cancer in mice have focused on mimicking genetic changes found in the human disease, particularly the activating KRAS mutations that occur in pancreatic tumors and their putative precursors, pancreatic intraepithelial neoplasia (PanIN). Although activated mouse Kras mutat...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585942/ https://ncbi.nlm.nih.gov/pubmed/19028876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810111105 |
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