Notch1 Is Not Required for Acinar-to-Ductal Metaplasia in a Model of Kras-Induced Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma is believed to arise from precursor lesions termed pancreatic intraepithelial neoplasia (PanIN). Mouse models have demonstrated that targeted expression of activated K-ras to mature acinar cells in the pancreas induces the spontaneous development of PanIN lesions; im...

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Bibliografiske detaljer
Main Authors: Avila, Jacqueline L., Troutman, Scott, Durham, Amy, Kissil, Joseph L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3526595/
https://ncbi.nlm.nih.gov/pubmed/23284900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052133
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