Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53

The Notch pathway has been implicated in a number of malignancies with different roles that are cell and tissue-type dependent. Notch1 is a putative oncogene in NSCLC and activation of the pathway represents a negative prognostic factor. To establish the role of Notch1 in lung adenocarcinoma we dire...

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Detalhes bibliográficos
Main Authors: Licciulli, Silvia, Avila, Jacqueline L., Hanlon, Linda, Troutman, Scott, Cesaroni, Matteo, Kota, Smitha, Keith, Brian, Simon, M. Celeste, Pure, Ellen, Radtke, Fred, Capobianco, Anthony J., Kissil, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791518/
https://ncbi.nlm.nih.gov/pubmed/23943799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1384
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