Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

K-ras is the most commonly mutated oncogene in pancreatic cancer and its activation in murine models is sufficient to recapitulate the spectrum of lesions seen in human pancreatic ductal adenocarcinoma (PDAC). Recent studies suggest that Notch receptor signaling becomes reactivated in a subset of PD...

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Detalhes bibliográficos
Main Authors: Hanlon, Linda, Avila, Jacqueline L., Demarest, Renée M., Troutman, Scott, Allen, Megan, Ratti, Francesca, Rustgi, Anil K., Stanger, Ben Z., Radtke, Fred, Adsay, Volkan, Long, Fenella, Capobianco, Anthony J., Kissil, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880196/
https://ncbi.nlm.nih.gov/pubmed/20484026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4645
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