Kras mutation rate precisely orchestrates ductal derived pancreatic intraepithelial neoplasia and pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States. Despite the high prevalence of Kras mutations in pancreatic cancer patients, murine models expressing the oncogenic mutant Kras (Kras(mut)) in mature pancreatic cells develop PDAC at a lo...

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Publicado en:Lab Invest
Autores principales: Singh, Kanchan, Pruski, Melissa, Bland, Rachael, Younes, Mamoun, Guha, Sushovan, Thosani, Nirav, Maitra, Anirban, Cash, Brooks D., McAllister, Florencia, Logsdon, Craig D., Chang, Jeffrey T., Bailey-Lundberg, Jennifer M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group US 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8172380/
https://ncbi.nlm.nih.gov/pubmed/33009500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-020-00490-5
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