Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

Tumors are largely classified by histological appearance, yet morphological features do not necessarily predict cellular origin. To determine the origin of pancreatic ductal adenocarcinoma (PDA), we labeled and traced pancreatic cell populations after induction of a PDA-initiating Kras mutation. Our...

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Detaylı Bibliyografya
Asıl Yazarlar: Kopp, Janel L., von Figura, Guido, Mayes, Erin, Liu, Fen-Fen, Dubois, Claire L., Morris, John P., Pan, Fong Cheng, Akiyama, Haruhiko, Wright, Christopher V. E., Jensen, Kristin, Hebrok, Matthias, Sander, Maike
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568632/
https://ncbi.nlm.nih.gov/pubmed/23201164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.10.025
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