Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma

Tumors are largely classified by histological appearance, yet morphological features do not necessarily predict cellular origin. To determine the origin of pancreatic ductal adenocarcinoma (PDA), we labeled and traced pancreatic cell populations after induction of a PDA-initiating Kras mutation. Our...

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Autori principali: Kopp, Janel L., von Figura, Guido, Mayes, Erin, Liu, Fen-Fen, Dubois, Claire L., Morris, John P., Pan, Fong Cheng, Akiyama, Haruhiko, Wright, Christopher V. E., Jensen, Kristin, Hebrok, Matthias, Sander, Maike
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568632/
https://ncbi.nlm.nih.gov/pubmed/23201164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.10.025
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