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Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration
The new concept of mammalian sex maintenance establishes that particular key genes must remain active in the differentiated gonads to avoid genetic sex reprogramming, as described in adult ovaries after Foxl2 ablation. Dmrt1 plays a similar role in postnatal testes, but the mechanism of adult testis...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945155/ https://ncbi.nlm.nih.gov/pubmed/27328324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15635 |
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