Structural analysis of multi-helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA

NMR and SAXS/WAXS are highly complementary approaches for the analysis of RNA structure in solution. Here we describe an efficient NMR-SAXS/WAXS approach for structural investigation of multi-helical RNAs. We illustrate this approach by determining the overall fold of a 92-nucleotide 3-helix junctio...

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Pubblicato in:J Mol Biol
Autori principali: Cornilescu, Gabriel, Didychuk, Allison L., Rodgers, Margaret L., Michael, Lauren A., Burke, Jordan E., Montemayor, Eric J., Hoskins, Aaron A., Butcher, Samuel E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4790120/
https://ncbi.nlm.nih.gov/pubmed/26655855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.11.026
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