Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA

The spliceosome removes introns from precursor messenger RNA (pre-mRNA) to produce mature mRNA. Prior to catalysis, spliceosomes are assembled de novo onto pre-mRNA substrates. During this assembly process, U6 small nuclear RNA (snRNA) undergoes extensive structural remodeling. The early stages of t...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Montemayor, Eric J., Didychuk, Allison L., Yake, Allyson D., Sidhu, Gurnimrat K., Brow, David A., Butcher, Samuel E.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931518/
https://ncbi.nlm.nih.gov/pubmed/29717126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04145-4
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