Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities

U6 small nuclear ribonucleoprotein (snRNP) biogenesis is essential for spliceosome assembly, but not well understood. Here, we report structures of the U6 RNA processing enzyme Usb1 from yeast and a substrate analog bound complex from humans. Unlike the human ortholog, we show that yeast Usb1 has cy...

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Publicat a:Nat Commun
Autors principals: Didychuk, Allison L., Montemayor, Eric J., Carrocci, Tucker J., DeLaitsch, Andrew T., Lucarelli, Stefani E., Westler, William M., Brow, David A., Hoskins, Aaron A., Butcher, Samuel E.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5591277/
https://ncbi.nlm.nih.gov/pubmed/28887445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00484-w
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