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Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

The spliceosome is a dynamic macromolecular machine that assembles on pre-mRNA substrates and catalyses the excision of non-coding intervening sequences (introns)1-3. Four of the five major components of the spliceosome, U1, U2, U4 and U5 snRNPs, contain seven Sm proteins (SmB/B’, SmD1, SmD2, SmD3,...

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Bibliographic Details
Main Authors: Leung, Adelaine K. W., Nagai, Kiyoshi, Li, Jade
Format: Artigo
Language:Inglês
Published: 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103711/
https://ncbi.nlm.nih.gov/pubmed/21516107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09956
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