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Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1
Post-transcriptional modification of snRNA is central to spliceosome function. Usb1 is an exoribonuclease that shortens the oligo-uridine tail of U6 snRNA, resulting in a terminal 2′,3′ cyclic phosphate group in most eukaryotes, including humans. Loss of function mutations in human Usb1 cause the ra...
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| Izdano u: | Nucleic Acids Res |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6265477/ https://ncbi.nlm.nih.gov/pubmed/30215753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky812 |
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