Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands

To explore the role of amphiregulin in inflammatory epidermal hyperplasia, we overexpressed human AREG (hAREG) in FVB/N mice using a bovine K5 promoter. A construct containing AREG coding sequences flanked by 5′ and 3′ untranslated region sequences (AREG-UTR) led to a >10-fold increase in hAREG e...

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Dettagli Bibliografici
Pubblicato in:Exp Dermatol
Autori principali: Li, Yong, Stoll, Stefan W., Sekhon, Sahil, Talsma, Caroline, Camhi, Maya I., Jones, Jennifer L., Lambert, Sylviane, Marley, Hue, Rittié, Laure, Grachtchouk, Marina, Fritz, Yi, Ward, Nicole L., Elder, James T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4789112/
https://ncbi.nlm.nih.gov/pubmed/26519132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/exd.12886
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