Amphiregulin and Epidermal Hyperplasia: Amphiregulin Is Required to Maintain the Psoriatic Phenotype of Human Skin Grafts on Severe Combined Immunodeficient Mice

Overexpression of amphiregulin has been shown to induce psoriasiform changes in the skin of transgenic mice shortly after birth. Therefore, amphiregulin has been suggested as a target for anti-psoriatic therapy. To test this theory, a humanized monoclonal antibody capable of neutralizing human amphi...

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Main Authors: Bhagavathula, Narasimharao, Nerusu, Kamalakar C., Fisher, Gary J., Liu, Gao, Thakur, Archana B., Gemmell, Lorraine, Kumar, Shankar, Xu, Zenghai H., Hinton, Paul, Tsurushita, Naoya, Landolfi, Nicholas F., Voorhees, John J., Varani, James
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2005
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Original Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780140/
https://ncbi.nlm.nih.gov/pubmed/15793282
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