Amphiregulin and Epidermal Hyperplasia: Amphiregulin Is Required to Maintain the Psoriatic Phenotype of Human Skin Grafts on Severe Combined Immunodeficient Mice

Overexpression of amphiregulin has been shown to induce psoriasiform changes in the skin of transgenic mice shortly after birth. Therefore, amphiregulin has been suggested as a target for anti-psoriatic therapy. To test this theory, a humanized monoclonal antibody capable of neutralizing human amphi...

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Autors principals: Bhagavathula, Narasimharao, Nerusu, Kamalakar C., Fisher, Gary J., Liu, Gao, Thakur, Archana B., Gemmell, Lorraine, Kumar, Shankar, Xu, Zenghai H., Hinton, Paul, Tsurushita, Naoya, Landolfi, Nicholas F., Voorhees, John J., Varani, James
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2005
Matèries:
Original Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1780140/
https://ncbi.nlm.nih.gov/pubmed/15793282
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