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Mitochondrial ClpP activity is required for cisplatin resistance in human cells
In human cells ClpP and ClpX are imported into the mitochondrial matrix, where they interact to form the ATP-dependent protease ClpXP and play a role in the mitochondrial unfolded protein response. We find that reducing the levels of mitochondrial ClpP or ClpX renders human cancer cells more sensiti...
में बचाया:
| में प्रकाशित: | Biochim Biophys Acta |
|---|---|
| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2015
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4788106/ https://ncbi.nlm.nih.gov/pubmed/26675528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2015.12.005 |
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