Prostaglandin E(2)-EP4 signaling persistently amplifies CD40-mediated induction of IL-23 p19 expression through canonical and non-canonical NF-κB pathways

While there is mounting evidence that interleukin (IL)-23-IL-17 axis plays a critical role in the pathogenesis of various autoimmune diseases, much remains to be elucidated on how IL-23 is induced in the pathological processes. IL-23 is a heterodimer composed of p19 and p40, the latter being shared...

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Foilsithe in:Cell Mol Immunol
Main Authors: Ma, Xiaojun, Aoki, Tomohiro, Narumiya, Shuh
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786633/
https://ncbi.nlm.nih.gov/pubmed/26189370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2015.70
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