T cell–intrinsic prostaglandin E(2)-EP2/EP4 signaling is critical in pathogenic T(H)17 cell–driven inflammation

BACKGROUND: IL-23 is the key cytokine for generation of pathogenic IL-17–producing helper T (T(H)17) cells, which contribute critically to autoimmune diseases. However, how IL-23 generates pathogenic T(H)17 cells remains to be elucidated. OBJECTIVES: We sought to examine the involvement, molecular m...

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Bibliografiska uppgifter
I publikationen:J Allergy Clin Immunol
Huvudupphovsmän: Lee, Jinju, Aoki, Tomohiro, Thumkeo, Dean, Siriwach, Ratklao, Yao, Chengcan, Narumiya, Shuh
Materialtyp: Artigo
Språk:Inglês
Publicerad: Mosby 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6354914/
https://ncbi.nlm.nih.gov/pubmed/29935220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2018.05.036
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