A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal thickening of the heart, but the earliest signs of disease are hyperdynamic contraction and impaired relaxation. Whereas some in...

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Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Green, Eric M., Wakimoto, Hiroko, Anderson, Robert L., Evanchik, Marc J., Gorham, Joshua M., Harrison, Brooke C., Henze, Marcus, Kawas, Raja, Oslob, Johan D., Rodriguez, Hector M., Song, Yonghong, Wan, William, Leinwand, Leslie A., Spudich, James A., McDowell, Robert S., Seidman, J. G., Seidman, Christine E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784435/
https://ncbi.nlm.nih.gov/pubmed/26912705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3456
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