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A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal thickening of the heart, but the earliest signs of disease are hyperdynamic contraction and impaired relaxation. Whereas some in...
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| 發表在: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4784435/ https://ncbi.nlm.nih.gov/pubmed/26912705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3456 |
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