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A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal thickening of the heart, but the earliest signs of disease are hyperdynamic contraction and impaired relaxation. Whereas some in...
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| 出版年: | Science |
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| 主要な著者: | , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4784435/ https://ncbi.nlm.nih.gov/pubmed/26912705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3456 |
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