A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is an inherited disease of the heart muscle characterized by otherwise unexplained thickening of the left ventricle. Left ventricular outflow tract (LVOT) obstruction is present in approximately two-thirds of patients and substantially increases the risk of disease...

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Udgivet i:PLoS One
Main Authors: Stern, Joshua A., Markova, Svetlana, Ueda, Yu, Kim, Jae B., Pascoe, Peter J., Evanchik, Marc J., Green, Eric M., Harris, Samantha P.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156432/
https://ncbi.nlm.nih.gov/pubmed/27973580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168407
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