A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice

Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal thickening of the heart, but the earliest signs of disease are hyperdynamic contraction and impaired relaxation. Whereas some in...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Science
Päätekijät: Green, Eric M., Wakimoto, Hiroko, Anderson, Robert L., Evanchik, Marc J., Gorham, Joshua M., Harrison, Brooke C., Henze, Marcus, Kawas, Raja, Oslob, Johan D., Rodriguez, Hector M., Song, Yonghong, Wan, William, Leinwand, Leslie A., Spudich, James A., McDowell, Robert S., Seidman, J. G., Seidman, Christine E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784435/
https://ncbi.nlm.nih.gov/pubmed/26912705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad3456
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