Development of a Rapid Throughput Assay for Identification of hNa(v)1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Voltage-gated sodium channels (VGSCs) are responsible for the generation of the action potential. Among nine classified VGSC subtypes (Na(v)1.1–Na(v)1.9), Na(v)1.7 is primarily expressed in the sensory neurons, contributing to the nociception transmission. Therefore Na(v)1.7 becomes a promising targ...

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Detalhes bibliográficos
Publicado no:Mar Drugs
Main Authors: Zhao, Fang, Li, Xichun, Jin, Liang, Zhang, Fan, Inoue, Masayuki, Yu, Boyang, Cao, Zhengyu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771989/
https://ncbi.nlm.nih.gov/pubmed/26891306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14020036
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