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Development of a Rapid Throughput Assay for Identification of hNa(v)1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin

Voltage-gated sodium channels (VGSCs) are responsible for the generation of the action potential. Among nine classified VGSC subtypes (Na(v)1.1–Na(v)1.9), Na(v)1.7 is primarily expressed in the sensory neurons, contributing to the nociception transmission. Therefore Na(v)1.7 becomes a promising targ...

詳細記述

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書誌詳細
出版年:Mar Drugs
主要な著者: Zhao, Fang, Li, Xichun, Jin, Liang, Zhang, Fan, Inoue, Masayuki, Yu, Boyang, Cao, Zhengyu
フォーマット: Artigo
言語:Inglês
出版事項: MDPI 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771989/
https://ncbi.nlm.nih.gov/pubmed/26891306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14020036
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