Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNa(v)1.2, rNa(v)1.4 and rNa(v)1.5 alpha subunits

BACKGROUND: Antillatoxin (ATX) is a structurally unique lipopeptide produced by the marine cyanobacterium Lyngbya majuscula. ATX activates voltage-gated sodium channel α-subunits at an undefined recognition site and stimulates sodium influx in neurons. However, the pharmacological properties and sel...

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Hlavní autoři: Cao, Zhengyu, Gerwick, William H, Murray, Thomas F
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009643/
https://ncbi.nlm.nih.gov/pubmed/21156065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-11-154
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