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Development of a Rapid Throughput Assay for Identification of hNa(v)1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin
Voltage-gated sodium channels (VGSCs) are responsible for the generation of the action potential. Among nine classified VGSC subtypes (Na(v)1.1–Na(v)1.9), Na(v)1.7 is primarily expressed in the sensory neurons, contributing to the nociception transmission. Therefore Na(v)1.7 becomes a promising targ...
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| Veröffentlicht in: | Mar Drugs |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
MDPI
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4771989/ https://ncbi.nlm.nih.gov/pubmed/26891306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14020036 |
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