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Partial Agonist and Antagonist Activities of a Mutant Scorpion β-Toxin on Sodium Channels
Scorpion β-toxin 4 from Centruroides suffusus suffusus (Css4) enhances the activation of voltage-gated sodium channels through a voltage sensor trapping mechanism by binding the activated state of the voltage sensor in domain II and stabilizing it in its activated conformation. Here we describe the...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2945547/ https://ncbi.nlm.nih.gov/pubmed/20682774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150888 |
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