Partial Agonist and Antagonist Activities of a Mutant Scorpion β-Toxin on Sodium Channels

Scorpion β-toxin 4 from Centruroides suffusus suffusus (Css4) enhances the activation of voltage-gated sodium channels through a voltage sensor trapping mechanism by binding the activated state of the voltage sensor in domain II and stabilizing it in its activated conformation. Here we describe the...

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Main Authors: Karbat, Izhar, Ilan, Nitza, Zhang, Joel Z., Cohen, Lior, Kahn, Roy, Benveniste, Morris, Scheuer, Todd, Catterall, William A., Gordon, Dalia, Gurevitz, Michael
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Membrane Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945547/
https://ncbi.nlm.nih.gov/pubmed/20682774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.150888
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