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Mapping the Interaction Site for a β-Scorpion Toxin in the Pore Module of Domain III of Voltage-gated Na(+) Channels

Activation of voltage-gated sodium (Na(v)) channels initiates and propagates action potentials in electrically excitable cells. β-Scorpion toxins, including toxin IV from Centruroides suffusus suffusus (CssIV), enhance activation of Na(V) channels. CssIV stabilizes the voltage sensor in domain II in...

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Dettagli Bibliografici
Autori principali: Zhang, Joel Z., Yarov-Yarovoy, Vladimir, Scheuer, Todd, Karbat, Izhar, Cohen, Lior, Gordon, Dalia, Gurevitz, Michael, Catterall, William A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436316/
https://ncbi.nlm.nih.gov/pubmed/22761417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.370742
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