Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels

Voltage-gated sodium (Na(v)) channels are the molecular targets of β-scorpion toxins, which shift the voltage dependence of activation to more negative membrane potentials by a voltage sensor-trapping mechanism. Molecular determinants of β-scorpion toxin (CssIV) binding and action on rat brain sodiu...

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Bibliographic Details
Main Authors: Zhang, Joel Z., Yarov-Yarovoy, Vladimir, Scheuer, Todd, Karbat, Izhar, Cohen, Lior, Gordon, Dalia, Gurevitz, Michael, Catterall, William A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3190924/
https://ncbi.nlm.nih.gov/pubmed/21795675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282509
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