Llwytho...

Mapping the receptor site for α-scorpion toxins on a Na(+) channel voltage sensor

The α-scorpions toxins bind to the resting state of Na(+) channels and inhibit fast inactivation by interaction with a receptor site formed by domains I and IV. Mutants T1560A, F1610A, and E1613A in domain IV had lower affinities for Leiurus quinquestriatus hebraeus toxin II (LqhII), and mutant E161...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Jinti, Yarov-Yarovoy, Vladimir, Kahn, Roy, Gordon, Dalia, Gurevitz, Michael, Scheuer, Todd, Catterall, William A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174582/
https://ncbi.nlm.nih.gov/pubmed/21876146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112320108
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