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Mapping the receptor site for α-scorpion toxins on a Na(+) channel voltage sensor
The α-scorpions toxins bind to the resting state of Na(+) channels and inhibit fast inactivation by interaction with a receptor site formed by domains I and IV. Mutants T1560A, F1610A, and E1613A in domain IV had lower affinities for Leiurus quinquestriatus hebraeus toxin II (LqhII), and mutant E161...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3174582/ https://ncbi.nlm.nih.gov/pubmed/21876146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112320108 |
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