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Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase

Catechol‐O‐methyltransferase (COMT), an important therapeutic target in the treatment of Parkinson's disease, is also being developed for biocatalytic processes, including vanillin production, although lack of regioselectivity has precluded its more widespread application. By using structural a...

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Сохранить в:
Библиографические подробности
Опубликовано в: :Angew Chem Int Ed Engl
Главные авторы: Law, Brian J. C., Bennett, Matthew R., Thompson, Mark L., Levy, Colin, Shepherd, Sarah A., Leys, David, Micklefield, Jason
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770447/
https://ncbi.nlm.nih.gov/pubmed/26797714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508287
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