Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase

Catechol‐O‐methyltransferase (COMT), an important therapeutic target in the treatment of Parkinson's disease, is also being developed for biocatalytic processes, including vanillin production, although lack of regioselectivity has precluded its more widespread application. By using structural a...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Law, Brian J. C., Bennett, Matthew R., Thompson, Mark L., Levy, Colin, Shepherd, Sarah A., Leys, David, Micklefield, Jason
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2016
Teme:
Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770447/
https://ncbi.nlm.nih.gov/pubmed/26797714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508287
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