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Site-specific bioalkylation of rapamycin by the RapM 16-O-methyltransferase
The methylation of natural products by S-adenosyl methionine (AdoMet, also known as SAM)-dependent methyltransferase enzymes is a common tailoring step in many biosynthetic pathways. The introduction of methyl substituents can affect the biological and physicochemical properties of the secondary met...
Kaydedildi:
| Yayımlandı: | Chem Sci |
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| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Royal Society of Chemistry
2015
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5729408/ https://ncbi.nlm.nih.gov/pubmed/29403635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc00164a |
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