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Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase

Catechol‐O‐methyltransferase (COMT), an important therapeutic target in the treatment of Parkinson's disease, is also being developed for biocatalytic processes, including vanillin production, although lack of regioselectivity has precluded its more widespread application. By using structural a...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Law, Brian J. C., Bennett, Matthew R., Thompson, Mark L., Levy, Colin, Shepherd, Sarah A., Leys, David, Micklefield, Jason
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770447/
https://ncbi.nlm.nih.gov/pubmed/26797714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508287
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