Effects of Active‐Site Modification and Quaternary Structure on the Regioselectivity of Catechol‐O‐Methyltransferase

Catechol‐O‐methyltransferase (COMT), an important therapeutic target in the treatment of Parkinson's disease, is also being developed for biocatalytic processes, including vanillin production, although lack of regioselectivity has precluded its more widespread application. By using structural a...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Law, Brian J. C., Bennett, Matthew R., Thompson, Mark L., Levy, Colin, Shepherd, Sarah A., Leys, David, Micklefield, Jason
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770447/
https://ncbi.nlm.nih.gov/pubmed/26797714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508287
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