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Regioselectivity of Catechol O-Methyltransferase Confers Enhancement of Catalytic Activity
Catechol O-methyltransferase (COMT) metabolizes catechol moieties by methylating a single hydroxyl group at the meta- or para- hydroxyl position. Hydrophobic amino acids near the active site of COMT influence the regioselectivity of this reaction. Our sequence analysis highlights their importance by...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3125089/ https://ncbi.nlm.nih.gov/pubmed/21731105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cplett.2011.03.048 |
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