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Regioselectivity of Catechol O-Methyltransferase Confers Enhancement of Catalytic Activity

Catechol O-methyltransferase (COMT) metabolizes catechol moieties by methylating a single hydroxyl group at the meta- or para- hydroxyl position. Hydrophobic amino acids near the active site of COMT influence the regioselectivity of this reaction. Our sequence analysis highlights their importance by...

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Detalhes bibliográficos
Main Authors: Tsao, Douglas, Liu, Shubin, Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125089/
https://ncbi.nlm.nih.gov/pubmed/21731105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cplett.2011.03.048
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