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Structural Mechanism of S-Adenosyl Methionine Binding to Catechol O-Methyltransferase

Methyltransferases possess a homologous domain that requires both a divalent metal cation and S-adenosyl-L-methionine (SAM) to catalyze its reactions. The kinetics of several methyltransferases has been well characterized; however, the details regarding their structural mechanisms have remained uncl...

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Detalhes bibliográficos
Main Authors: Tsao, Douglas, Diatchenko, Luda, Dokholyan, Nikolay V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3164188/
https://ncbi.nlm.nih.gov/pubmed/21904625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024287
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