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Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine
Flavivirus methyltransferase is a genetically-validated antiviral target. Crystal structures of almost all available flavivirus methyltransferases contain S-adenosyl-L-methionine (SAM), the methyl donor molecule that co-purifies with the enzymes. This raises a possibility that SAM is an integral str...
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| Gepubliceerd in: | Antiviral Res |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Elsevier B.V.
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7113791/ https://ncbi.nlm.nih.gov/pubmed/25241250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2014.09.003 |
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