Crystal Structure of the Dengue Virus Methyltransferase Bound to a 5′-Capped Octameric RNA

The N-terminal domain of the flavivirus NS5 protein functions as a methyltransferase (MTase). It sequentially methylates the N7 and 2′-O positions of the viral RNA cap structure (GpppA→(7me)GpppA→(7me)GpppA(2′-O-me)). The same NS5 domain could also have a guanylyltransferase activity (GTP+ppA-RNA→Gp...

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Autores principales: Yap, Li Jian, Luo, Dahai, Chung, Ka Yan, Lim, Siew Pheng, Bodenreider, Christophe, Noble, Christian, Shi, Pei-Yong, Lescar, Julien
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2941465/
https://ncbi.nlm.nih.gov/pubmed/20862256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012836
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