Conformational Flexibility of the Dengue Virus RNA-Dependent RNA Polymerase Revealed by a Complex with an Inhibitor

We report a highly reproducible method to crystallize the RNA-dependent RNA polymerase (RdRp) domain of dengue virus serotype 3 (DENV-3), allowing structure refinement to a 1.79-Å resolution and revealing amino acids not seen previously. We also present a DENV-3 polymerase/inhibitor cocrystal struct...

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Bibliographic Details
Main Authors: Noble, Christian G., Lim, Siew Pheng, Chen, Yen-Liang, Liew, Chong Wai, Yap, Lijian, Lescar, Julien, Shi, Pei-Yong
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624333/
https://ncbi.nlm.nih.gov/pubmed/23408636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00045-13
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