Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase

BACKGROUND: Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Specifically, low COMT activity is associated with heightened pain perception and development of musculoskeletal pain in humans as well as increased exp...

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Bibliographic Details
Main Authors: Tchivileva, Inna E, Nackley, Andrea G, Qian, Li, Wentworth, Sean, Conrad, Matthew, Diatchenko, Luda B
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662804/
https://ncbi.nlm.nih.gov/pubmed/19291302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-13
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