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Characterization of NF-kB-mediated inhibition of catechol-O-methyltransferase

BACKGROUND: Catechol-O-methyltransferase (COMT), an enzyme that metabolizes catecholamines, has recently been implicated in the modulation of pain. Specifically, low COMT activity is associated with heightened pain perception and development of musculoskeletal pain in humans as well as increased exp...

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Detalhes bibliográficos
Main Authors: Tchivileva, Inna E, Nackley, Andrea G, Qian, Li, Wentworth, Sean, Conrad, Matthew, Diatchenko, Luda B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2662804/
https://ncbi.nlm.nih.gov/pubmed/19291302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-5-13
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