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Disruptive mRNA folding increases translational efficiency of catechol-O-methyltransferase variant

Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. There are three common COMT haplotypes in the human population reported to have functional effects, divergent in two synonymous and one n...

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Detalhes bibliográficos
Main Authors: Tsao, Douglas, Shabalina, Svetlana A., Gauthier, Josée, Dokholyan, Nikolay V., Diatchenko, Luda
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152328/
https://ncbi.nlm.nih.gov/pubmed/21486747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr165
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