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Disruptive mRNA folding increases translational efficiency of catechol-O-methyltransferase variant

Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. There are three common COMT haplotypes in the human population reported to have functional effects, divergent in two synonymous and one n...

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Bibliografiske detaljer
Main Authors: Tsao, Douglas, Shabalina, Svetlana A., Gauthier, Josée, Dokholyan, Nikolay V., Diatchenko, Luda
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152328/
https://ncbi.nlm.nih.gov/pubmed/21486747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr165
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