Disruptive mRNA folding increases translational efficiency of catechol-O-methyltransferase variant

Catechol-O-methyltransferase (COMT) is a major enzyme controlling catecholamine levels that plays a central role in cognition, affective mood and pain perception. There are three common COMT haplotypes in the human population reported to have functional effects, divergent in two synonymous and one n...

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Autori principali: Tsao, Douglas, Shabalina, Svetlana A., Gauthier, Josée, Dokholyan, Nikolay V., Diatchenko, Luda
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
RNA
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152328/
https://ncbi.nlm.nih.gov/pubmed/21486747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr165
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