NF-κB Restricts inflammasome activation via elimination of damaged mitochondria

NF-κB, a key activator of inflammation primes the NLRP3-inflammasome for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB, however, also prevents excessive inflammation and restrains NLRP3-inflammasome activation through a poorly defined mechanism. We now show that NF-κB exerts its anti-...

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Publicado no:Cell
Main Authors: Zhong, Zhenyu, Umemura, Atsushi, Sanchez-Lopez, Elsa, Liang, Shuang, Shalapour, Shabnam, Wong, Jerry, He, Feng, Boassa, Daniela, Perkins, Guy, Ali, Syed Raza, McGeough, Matthew G., Ellisman, Mark H., Seki, Ekihiro, Gustafsson, Asa B., Hoffman, Hal M., Diaz-Meco, Maria T., Moscat, Jorge, Karin, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769378/
https://ncbi.nlm.nih.gov/pubmed/26919428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.12.057
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