New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Dysregulated NLRP3 inflammasome activity results in uncontrolled inflammation, which underlies many chronic diseases. Although mitochondrial damage is needed for the assembly and activation of the NLRP3 inflammasome, it is unclear how macrophages are able to respond to structurally diverse inflammas...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Zhong, Zhenyu, Liang, Shuang, Sanchez-Lopez, Elsa, He, Feng, Shalapour, Shabnam, Lin, Xue-jia, Wong, Jerry, Ding, Siyuan, Seki, Ekihiro, Schnabl, Bernd, Hevener, Andrea L., Greenberg, Harry B., Kisseleva, Tatiana, Karin, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329306/
https://ncbi.nlm.nih.gov/pubmed/30046112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0372-z
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