New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

Dysregulated NLRP3 inflammasome activity results in uncontrolled inflammation, which underlies many chronic diseases. Although mitochondrial damage is needed for the assembly and activation of the NLRP3 inflammasome, it is unclear how macrophages are able to respond to structurally diverse inflammas...

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Pubblicato in:Nature
Autori principali: Zhong, Zhenyu, Liang, Shuang, Sanchez-Lopez, Elsa, He, Feng, Shalapour, Shabnam, Lin, Xue-jia, Wong, Jerry, Ding, Siyuan, Seki, Ekihiro, Schnabl, Bernd, Hevener, Andrea L., Greenberg, Harry B., Kisseleva, Tatiana, Karin, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329306/
https://ncbi.nlm.nih.gov/pubmed/30046112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0372-z
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